One approach to gene therapy uses special viruses that have been modified in the lab. Gene therapy treats the disease through the introduction of new cells to kill cancer cells or enable more effective use of other treatment types.
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Suicide gene therapy provides amazing potential for new and effective treatments for all kinds of cancer including mesothelioma and lung cancer.
Mesothelioma gene. Mesothelioma gene therapy uses genes from healthy cells to help kill cancerous genes within mesothelioma cancer cells by turning on the newly introduced genetic materials. The virus is injected into the pleural space and infects the mesothelioma cells. While the gene therapy didnt lead to a complete disease response it did help stop mesotheliomas growth in many cases.
The gene is located on the short arm of chromosome three. This gene is overexpressed in mesothelioma tumors and aids the cancer cells proliferation. Gene therapy is an exciting area of research especially for patients living with diseases like mesothelioma.
A newer type of treatment being tested on mesothelioma is gene therapy which attempts to add new genes to cancer cells to make them easier to kill. Gene manipulation is becoming easier safer and faster as technology improves. Mesothelioma gene therapy is an emerging treatment type that is currently available to patients through participation in clinical trials.
For example if a tumor suppressing gene is damaged this is a sign of a more aggressive disease. In a 2011 study conducted at the university of hawaii cancer center and fox chase cancer center in philadelphia researchers discovered people who carry a mutation in a gene called bap1 are susceptible to developing mesothelioma. Ezh2 is connected to the loss of bap1 which is another gene.
How tazemetostat works for mesothelioma treatment. Bap1 gene and mesothelioma. Doctors can also look for high levels of genes that create immune suppressing proteins like pd l1 and b7.
When introduced to the body the genes cause the mesothelioma cells to produce a protein that prohibits the cancerous cells from replicating. Doctors can predict the aggressiveness of a mesothelioma by studying the cells gene expression.
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Figure 3 Significantly Mutated Mesothelioma Genes
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